We at Clean Green Biosystems have developed a noval technology of extracting highly bio available cannabinoid extract from fresh cannabis plants.
Cannabis fresh plant’s cell fragmentation under intense hydrodynamic shear force releases bioactive compounds from cells, because of epidermis breaking, cuticle disintegration and membrane disintegration. In this case, the bioactive compounds to be released and dissolved into a aqueous phase are enclosed in an insoluble structure. In order to release these bio active compounds, the cell membrane must be broken down. Cell disruption is a sensitive process, and control of the cell disruption is required, to avoid uncontrolled release of cell debris or product denaturation. Hydrodynamic force is a well-controllable means for cell disintegration. It provides faster and more complete release of bio active compounds into a aqueous media, improves the mass transfer. Hydrodynamic shear waves disrupt cell walls and releases a full spectrum matrix of compounds. As the fluid waves breaks the cell wall mechanically by the shear forces, it facilitates the transfer from the cell into the solvent. Particle size reduction also increases the surface area in contact between the solid and the liquid. The solvent can enter the cell transporting essential oils and bioactive compounds from the cell interior into the surrounding solvent. This enables us to produce high-potency extracts, with the highest contents of phenols, flavonoids, non-flavonoids, carotenoids, terpenoids, phytosterols, etc. In an engineering sense, hydrodynamic shear force can be manipulated, as a control parameter, to enhance the extraction process.
Bioavailability is an extremely important concept in pharmacology. The Merriam-Webster dictionary defines it as: the degree and rate at which a substance (as a drug) is absorbed into a living system or is made available at the site of physiological activity. In order for a medicine to work, it has to reach its intended destination.
The bio availability of existing cannabinoids are the range of 10-35%. This poor bio availability results in poor pharmacological activity which requires high and repetitive dosages.
This current process produces a highly bio available phyto cannabinoids (a full spectrum cannabis extract).